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KMID : 0861120140180030069
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Korean Journal of Oriental Preventive Medicine
2014 Volume.18 No. 3 p.69 ~ p.80
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Anti-allergic effects of So-Cheong-Ryong-Tang in ovalbumin-induced allergic rhinitis model
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Kim Il-hwan
Ku Jin-mo
Hur Han-sol
Na Chang-hyeok
Jang Bo-Hyoung
Shin Yong-Cheol
Ko Seong-Gyu
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Abstract
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Objective : Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. Socheongryong-Tangtraditionally has been used in Korea for treatment of allergy diseases. In the present study, we investigatedwhether SCRT suppresses the progression of AR in vivo and in vitro.
Method : In this study, we investigated the effect of oral administration of SCRT on the Ovalbumin(OVA)-induced allergic rhinitis mouse models. Additionally, to find a possible explanation for the anti-inflammationeffects of SCRT, we evaluated the inflammatory cytokine levels in LPS-stimulated mouse inflammationcell (RAW264.7) and mouse splenocyte.
Results : The finding of this study demonstrated that SCRT reduced mast cells and inflammation cellsinfiltration in OVA-induced nasal cavity. Additionally, SCRT inhibited the production of inflammatorycytokines in splenocyte. However SCRT don’t inhibited the production of inflammatory cytokines in RAW264.7cells.
Conclusion : Taken together, our results showed that oral administration of SCRT beneficial effects in allergicrhinitis, suggesting that SCRT might be a useful candidate for the treatment of allergic rhinitis.
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KEYWORD
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allergic rhinitis, inflammation, ovalbumin, mast cells, RAW264.7 cells, Socheongryong- Tang
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